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Hereditary motor and sensory neuroapthy type 1(HMSN I)is an autosomal dominant disorder genetically localized on chromosome 1 in a few families and on chromosome 17 in other families.We analyzed linkage between 6 markers of chromosome 1,2 markers of chromosome 17,and the HMSN I locus using restriction fratment length polymorphisms and serotyping for the Duffy blood group in 5 families with HMSN I.Only in 1 of these families is linkage present between the disease locus and the loci for Duffy blood group and glucocerebrosidase(chromosome 1 markers).In the 4 other families the HMSN I locus is linked to the chromosome 17 markers pWE301 and pA10- 41. |
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